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KMID : 0352419940130020192
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Keimyung Medical Journal
1994 Volume.13 No. 2 p.192 ~ p.199
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Mutant p53 protein expression in keratoacanthoma and squamous cell carcinoma
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박의수
오광열/권건영/이규석/송준영
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Abstract
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Mutations in the p53 gene are the most frequent genetic alterations found in human cancers to date. The tumor suppressor gene p53, located on the short arm of chromosome 17, encodes for a nuclear protein which regulates cell proliferation by
inhibiting
cells entering S-phase.
We studies mutant p53 oncoprotein expression using DO7 monoclonal antibody immunohistochemically, in 12 keratoacanthomas(KAs) and 11 well-, 8 moderately and, 2 poorly differentiated squamous cell carcinomas(SCCs) of the skin. P53 immunoreactivity
was
observed in 67%(8 of 12) of KAs and 62%(13/21) SCCs were developed on ultraviolet-light exposure area. We compared staining pattern of p53 protein in the lesions of KAs and SCCs but do not find clear-cut distinction between the two lesions.
However
accumulation of p53 protein may play a role in the tumorigenesis of KAs and SCCs.
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KEYWORD
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